Protein aggregation is a process by which proteins clump together to form insoluble aggregates. This can occur during protein production, purification, or storage, and can lead to a loss of protein function and activity. There are a number of factors that can contribute to protein aggregation, including:
- High protein concentration
- Low pH
- High temperature
- Presence of denaturants
- Protein misfolding
There are a number of strategies that can be used to avoid protein aggregation, including:
